South Korea Car-T Cell Therapy Market SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (undefined)

South Korea Car-T Cell Therapy Market is Segmented By Targeted Antigen (CD19, CD20, BCMA, GCP-3, Claudin 18.2), By Therapeutic Application (B-cell non-Hodgkin\'s lymphoma, Multiple Myeloma, Cervical Cancer, Gastric Cancer, Lung Cancer, Others). The report offers the value (in USD Million) for the above-mentioned segments

South Korea Car-T Cell Therapy Market Trends

Market Driver – High Efficiency of CAR-T Cell Therapy in Treatment of Various Cancers

CAR-T cell therapy is showing very promising results in treating various difficult-to-treat cancers in South Korea. The high efficiency of CAR-T cells in eliminating cancer cells is one of the major factors fueling the growth of CAR-T cell therapy market in the country.

CAR-T cell therapy works by extracting T cells from patient's blood and genetically modifying them to recognize and attack cancer cells in a highly targeted way. Once injected back into the patient, these modified CAR-T cells can selectively identify and kill cancer cells without harming normal cells. For instance, according to a study published in The New England Journal of Medicine in 2022, CAR-T cell therapy tisagenlecleucel led to complete remission in 81% of adult patients with relapsed or refractory diffuse large B-cell lymphoma.

The ability of CAR-T cells to combat even highly resistant and recurring cancers that do not respond well to traditional therapies is driving its increased adoption. As South Korean cancer patients and their physicians get more exposure to successful CAR-T cell therapy outcomes globally, its demand is expected to grow significantly.

Market Driver – Robust Pipeline of CAR-T Cell Therapy Candidates

South Korea has been making rapid strides in the development of CAR-T cell therapy for various cancers over the past few years. The country has a robust pipeline of CAR-T therapy candidates that are driving significant growth within the CAR-T cell therapy market. Several local biotech and pharmaceutical companies are conducting clinical trials for different types of blood cancers with promising results.

For instance, Anthropic is developing CAR-T therapies for acute lymphoblastic leukemia and lymphoma through genetic engineering techniques like self-supervision. Their trials have shown enhanced cell viability and stronger anti-tumor effects compared to first-generation CAR-T therapies. Similarly, Huono Therapeutics is conducting Phase 1/2 trials of an anti-BCMA CAR-T therapy for multiple myeloma patients who have failed other lines of treatment. Early results demonstrate high response rates with a favorable safety profile.

The government is also supporting these efforts through initiatives like the Korean Cell Therapy Manufacturing Innovation Center established in 2021. This aims to help local companies scale up advanced therapies like CAR-T commercially. Government grants and subsidies through agencies like the Ministry of Health and Welfare are expediting clinical research.

South Korea Car-T Cell Therapy Market Key Factors

Market Challenge – Side Effects Associated with CAR-T Cell Therapy

One of the major factors restraining the growth of the CAR-T cell therapy market in South Korea is the serious side effects associated with this treatment. CAR-T cell therapy involves genetically modifying a patient's own T cells to attack cancer cells. While this approach has shown promising results in treating certain cancers, it can also cause deadly side effects in some patients. The modified T cells, in their overactive fight against cancer, end up attacking the patient's normal cells as well, which can lead to dangerous inflammatory responses in the body. Patients have reported experiencing severe cytokine release syndrome and neurologic toxicities after undergoing CAR-T cell therapy.

The risks and uncertainties associated with CAR-T cell therapy side effects are making both doctors and patients hesitant to adopt this treatment approach. According to a 2020 study conducted by the Korea Centers for Disease Control and Prevention, out of the 44 adults who received CAR-T cell therapy for blood cancer at various hospitals in South Korea between 2017 to 2019, serious side effects were reported in 27 patients.

Market Opportunity – The Use of Various Technological Platforms for the Development of CAR-T Therapies

The use of various technological platforms for the development of CAR-T therapies presents a major opportunity in South Korea's CAR-T cell therapy market. South Korea has a highly educated population and world-class research universities that are making advances in biomedical technologies. Leveraging these strengths to accelerate research on innovative CAR-T therapy delivery platforms could give South Korean companies a first-mover advantage in this emerging field.

Several universities in South Korea are exploring new techniques for engineering CAR-T cells. For example, researchers at Korea University are developing novel gene editing platforms using CRISPR/Cas9 technology to improve the targeting ability and safety of CAR-T therapies. Preliminary research suggests their CRISPR-modified CAR-T cells show enhanced cancer cell killing ability with reduced off-target toxicity in animal models. Continued research on cutting-edge gene engineering methods could enable South Korean companies to design more effective CAR-T therapies. Additionally, Korean scientists are experimenting with innovative delivery vehicles for CAR-T cells. For instance, a team at Ulsan National Institute of Science and Technology has demonstrated the potential of an injectable hydrogel to protect CAR-T cells and allow for sustained release at tumor sites in preclinical trials.